On 5th of April, 2025, the First International Symposium of the Serbian Group on Primary Immunodeficiencies (SGPI 2025) was held in Belgrade, which is an extremely important scientific and professional conference, whose goal is to emphasize the importance of a multidisciplinary approach in the diagnosis and treatment of patients with congenital disorders of the immune system (Inborn Errors of Immunity, IEI). This symposium is designed as a platform for the exchange of opinions and experiences through active discussion of participants, but also as an opportunity to connect with colleagues from the country and abroad, in order to plan and develop institutional and international cooperation, as well as to improve expertise in the process of diagnosis and treatment of IEI, but also to improve the quality of life of patients.